Clyde Edwards-Helaire of the Kansas City Chiefs is set to miss at least four games due to an unspecified illness, as he is being placed on the reserve/non-football illness list. This development comes after a training camp where he struggled with a recurring illness and has been open about dealing with post-traumatic stress disorder. With Edwards-Helaire sidelined, Isiah Pacheco is expected to take on the primary running back role, while Samaje Perine will step in as a key backup.

The Kansas City Chiefs have decided to release running back Deneric Prince, as reported by Sam McDowell of The Kansas City Star. Despite showing promise early in training camp, Prince has struggled to maintain his performance, leading to his departure from the team for the second consecutive year.

Head Coach Andy Reid confirmed that RB Clyde Edwards-Helaire will be the starter for the Kansas City Chiefs in Week 14 against the Buffalo Bills. While it's unclear how the workload will be split among the Chiefs' running backs, Edwards-Helaire is expected to receive a significant portion of the work. Jerick McKinnon is also in the mix, along with practice-squad RBs La'Mical Perine, Deneric Prince, and Keaontay Ingram.