In this article, Tristan H. Cockcroft provides matchup rankings for Week 18 of the NFL season, focusing on favorable and unfavorable matchups for quarterbacks, running backs, wide receivers, and tight ends. With the NFC North title and conference's No. 1 seed on the line, the Vikings-Lions game stands out, especially for players like Sam Darnold and Jameson Williams. The analysis includes insights on player performances and defensive matchups to help fantasy managers make informed lineup decisions.

In a thrilling matchup against the Lions, Isaac Guerendo showcased his ability to bounce back from injuries, contributing significantly to the 49ers' offense. Despite the team's loss, Guerendo's performance highlighted his potential as a valuable asset in fantasy football moving forward. With the uncertainty surrounding the starting quarterback position, his role may expand in the upcoming games.

Isaac Guerendo of the San Francisco 49ers has been cleared to play in Week 17 after recovering from foot and hamstring injuries. He participated fully in practice and is expected to resume his role as the team's lead running back against the Detroit Lions. Guerendo is currently ranked 17th among running backs for the week, indicating a strong potential for fantasy points.

San Francisco 49ers running back Isaac Guerendo is set to return to action on Monday night against the Detroit Lions after missing last week due to a hamstring injury. Guerendo's return comes at a crucial time as the 49ers have been dealing with multiple injuries in their backfield. He has shown promise in his previous games, rushing for a total of 135 yards over two weeks before his injury. With Guerendo back, the 49ers will have additional depth at running back as they look to bounce back against the Lions.

Isaac Guerendo, running back for the San Francisco 49ers, has been cleared to play in Week 17 against the Detroit Lions after recovering from foot and hamstring injuries. He had previously missed Week 16 due to a severe hamstring injury but is expected to lead the 49ers' backfield following a strong performance in Weeks 14 and 15, where he accumulated significant touches and yardage.

San Francisco 49ers running back Isaac Guerendo is set to return to action against the Detroit Lions after missing a game due to a hamstring injury. Guerendo had stepped up as a starter due to multiple injuries in the backfield, showcasing his potential with a solid performance against the Chicago Bears. His return comes at a crucial time for the 49ers as they navigate through a challenging injury situation at the running back position.

Isaac Guerendo, a running back for the San Francisco 49ers, is expected to return for Week 17 after missing Week 16 due to a hamstring injury. Despite being limited in practice, he is anticipated to take on a lead role in the backfield, following a productive stretch in Weeks 14 and 15 where he totaled 203 yards from scrimmage and two rushing touchdowns.

Isaac Guerendo, running back for the San Francisco 49ers, has been dealing with foot and hamstring injuries. After missing Week 16's game against the Dolphins, he returned to practice in a limited capacity ahead of Week 17. His status for the upcoming game against the Lions remains uncertain, but if cleared, he is expected to reclaim his role as the lead runner for the 49ers.

Isaac Guerendo of the 49ers has returned to limited practice after dealing with foot and hamstring injuries. His participation raises hopes for his availability in the upcoming game against the Lions. If he is cleared to play, he could be a viable RB2 option for fantasy football managers.

Isaac Guerendo, running back for the San Francisco 49ers, is set to be limited in practice due to ongoing foot and hamstring injuries. After missing Week 16, he is making a return to practice, which could be beneficial for the 49ers as they face the Lions in Week 17 without key players Christian McCaffrey and Jordan Mason. His ability to participate in practice this week will be crucial for his availability in the upcoming game.

The San Francisco 49ers have announced that left tackle Trent Williams, left guard Aaron Banks, and backup tackle Jaylon Moore will miss the remainder of the season due to injuries. This comes after the team was officially eliminated from postseason contention. Coach Kyle Shanahan expressed concerns about the team's offensive line depth and indicated that linebacker Dre Greenlaw and offensive lineman Spencer Burford are also dealing with injuries, which could further impact the roster. The 49ers are looking to make adjustments to their offensive line as they prepare for their final games of the season.

Isaac Guerendo, running back for the San Francisco 49ers, is expected to return to practice on Thursday after missing the previous week due to foot and hamstring injuries. His absence in Week 16 led to Patrick Taylor starting in his place, who struggled to make an impact. The 49ers are hopeful that Guerendo's return will bolster their backfield as they navigate through a series of injuries.

San Francisco 49ers running back Isaac Guerendo will miss the upcoming game against the Miami Dolphins due to a foot and hamstring injury. This leaves the 49ers with a limited backfield, featuring Patrick Taylor, Ke'Shawn Vaughn, and Israel Abanikanda. The situation is complicated by a tough matchup against a Dolphins defense that has been strong against opposing running backs recently.

With Isaac Guerendo ruled out due to a hamstring injury, Patrick Taylor is set to take on a larger role for the San Francisco 49ers in their upcoming game against the Miami Dolphins. Taylor briefly showcased his potential in Week 14 when he scored a touchdown after Guerendo's exit. However, the 49ers' offense has struggled this season compared to previous years, and the absence of star left tackle Trent Williams adds to the challenges.

San Francisco 49ers running back Isaac Guerendo has been ruled out for Week 16 due to a hamstring injury. He did not practice this week and is expected to miss time beyond Sunday. With Guerendo sidelined, Patrick Taylor and Israel Abanikanda are set to lead the backfield for the 49ers, with Ke'Shawn Vaughn likely being called up from the practice squad.

San Francisco 49ers running back Isaac Guerendo is expected to miss the upcoming game against the Miami Dolphins due to a hamstring injury. Guerendo has emerged as the primary back for the 49ers following a series of season-ending injuries to other key players in the position. The team is also facing challenges with the potential absence of left tackle Trent Williams, further complicating their offensive lineup as they fight for a playoff spot.

San Francisco 49ers running back Isaac Guerendo is expected to miss the upcoming game against the Miami Dolphins due to a hamstring injury. This season has been challenging for the 49ers' running back depth chart, which has been severely impacted by injuries to key players like Christian McCaffrey, Jordan Mason, and Elijah Mitchell. With Guerendo's absence, the 49ers will rely on other running backs on their roster, including Patrick Taylor Jr. and Israel Abanikanda.

49ers running back Isaac Guerendo is reported to be unlikely to play in the upcoming game against Miami due to a hamstring injury. This news could impact the 49ers' backfield strategy and fantasy football lineups.

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a hamstring injury that is likely to keep him out of the upcoming game against the Miami Dolphins. Despite a strong performance in his first NFL start, Guerendo's recent injury issues have raised concerns about his availability and impact on the team's backfield depth.

Isaac Guerendo, running back for the San Francisco 49ers, is dealing with a foot and a new hamstring injury, which has kept him from practicing on Wednesday. He managed to play through the foot issue last Thursday, but his availability for the upcoming game against the Dolphins is now in question. If Guerendo is unable to play, Patrick Taylor is expected to step in as the lead back for the 49ers.

Isaac Guerendo, running back for the San Francisco 49ers, is dealing with a hamstring injury that has sidelined him from practice. This comes after he played through a foot injury in a recent game against the Rams. With key players like Christian McCaffrey and Jordan Mason on injured reserve, the 49ers are taking a cautious approach with Guerendo's health as they prepare for their upcoming matchup against the Dolphins.

In a tough matchup against the Rams, Isaac Guerendo of the San Francisco 49ers managed to accumulate 75 total yards despite the team's 12-6 loss. The rookie running back, who recently recovered from a foot sprain, showcased his ability to handle a heavy workload in adverse weather conditions. With a solid performance, he is expected to maintain a secure fantasy floor as the lead back in upcoming games.

Isaac Guerendo, the rookie running back for the San Francisco 49ers, has been declared active for the Week 15 matchup against the Los Angeles Rams despite dealing with a sprained foot. After a limited practice on Wednesday, Guerendo expressed confidence in his ability to play. He previously showcased his potential with an impressive performance in his first NFL start, where he accumulated 128 scrimmage yards and two touchdowns.

Isaac Guerendo, the rookie running back for the San Francisco 49ers, is active for tonight's game against the Los Angeles Rams despite being listed as questionable due to a foot injury. He had a limited practice earlier in the week but has downplayed the injury and is expected to play. His workload remains uncertain, making him a risk/reward option for fantasy players. Other active running backs for the 49ers include Patrick Taylor and Ke'Shawn Vaughn, while Israel Abanikanda is a healthy scratch.

Isaac Guerendo, the rookie running back for the San Francisco 49ers, is planning to play in Thursday's game against the Rams despite dealing with a sprained foot. After a strong performance in his first NFL start against the Bears, where he rushed for 78 yards and two touchdowns, Guerendo's status remains questionable as the team monitors his recovery. With key players like Christian McCaffrey and Jordan Mason on injured reserve, Guerendo's role is crucial for the 49ers.